AustralieFrV1, Main, Exploration, bibRecord, 005E81

Alcohol consumption and pancreatic cancer: a pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4)

Identifieur interne : 005E81 ( Main/Exploration ); précédent : 005E80; suivant : 005E82

Alcohol consumption and pancreatic cancer: a pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4)

Auteurs : E. Lucenteforte [Italie] ; C. La Vecchia [Italie] ; D. Silverman [États-Unis] ; G. M. Petersen [États-Unis] ; P. M. Bracci [États-Unis] ; B. T. Ji [États-Unis] ; C. Bosetti [Italie] ; D. Li [États-Unis] ; S. Gallinger [États-Unis] ; A. B. Miller [Canada] ; H. B. Bueno-De-Mesquita [Pays-Bas] ; R. Talamini [Italie] ; J. Polesel [Italie] ; P. Ghadirian [Canada] ; P. A. Baghurst [Australie] ; W. Zatonski [Pologne] ; E. Fontham [États-Unis] ; W. R. Bamlet [États-Unis] ; E. A. Holly [États-Unis] ; Y. T. Gao [République populaire de Chine] ; E. Negri [Italie] ; M. Hassan [États-Unis] ; M. Cotterchio [Canada] ; J. Su [États-Unis] ; P. Maisonneuve [Italie] ; P. Boffetta [France, États-Unis] ; E. J. Duell [France, Espagne]

Source :

Annals of oncology [ 0923-7534 ] ; 2012.

RBID : Pascal:12-0135689

Descripteurs français

Pascal (Inist)
- Consommation, Boisson alcoolisée, Cancer du pancréas, Analyse, International, Homme, Etude cas témoin, Ethanol, Facteur risque, Epidémiologie.
Wicri :
- topic : Consommation, Boisson alcoolisée, Homme.

English descriptors

KwdEn :
- Alcoholic beverage, Analysis, Case control study, Consumption, Epidemiology, Ethanol, Human, International, Pancreas cancer, Risk factor.

Abstract

Background: Heavy alcohol drinking has been related to pancreatic cancer, but the issue is still unsolved. Methods: To evaluate the role of alcohol consumption in relation to pancreatic cancer, we conducted a pooled analysis of 10 case-control studies (5585 cases and 11 827 controls) participating in the International Pancreatic Cancer Case-Control Consortium. We computed pooled odds ratios (ORs) by estimating study-specific ORs adjusted for selected covariates and pooling them using random effects models. Results: Compared with abstainers and occasional drinkers (<1 drink per day), we observed no association for light-to-moderate alcohol consumption (<4 drinks per day) and pancreatic cancer risk; however, associations were above unity for higher consumption levels (OR = 1.6, 95% confidence interval 1.2-2.2 for subjects drinking ≥9 drinks per day). Results did not change substantially when we evaluated associations by tobacco smoking status, or when we excluded participants who reported a history of pancreatitis, or participants whose data were based upon proxy responses. Further, no notable differences in pooled risk estimates emerged across strata of sex, age, race, study type, and study area. Conclusion: This collaborative-pooled analysis provides additional evidence for a positive association between heavy alcohol consumption and the risk of pancreatic cancer.

Affiliations:

Australie, Canada, Espagne, France, Italie, Pays-Bas, Pologne, République populaire de Chine, États-Unis
Auvergne-Rhône-Alpes, Californie, Catalogne, Lombardie, Ontario, Québec, Rhône-Alpes, Texas, Utrecht (province), État de New York
Barcelone, Houston, Lyon, Milan, Montréal, San Francisco, Toronto, Utrecht
Université de Toronto

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Le document en format XML

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<author><name sortKey="Bamlet, W R" sort="Bamlet, W R" uniqKey="Bamlet W" first="W. R." last="Bamlet">W. R. Bamlet</name>
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<author><name sortKey="Negri, E" sort="Negri, E" uniqKey="Negri E" first="E." last="Negri">E. Negri</name>
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<author><name sortKey="Hassan, M" sort="Hassan, M" uniqKey="Hassan M" first="M." last="Hassan">M. Hassan</name>
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<author><name sortKey="Maisonneuve, P" sort="Maisonneuve, P" uniqKey="Maisonneuve P" first="P." last="Maisonneuve">P. Maisonneuve</name>
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<author><name sortKey="Boffetta, P" sort="Boffetta, P" uniqKey="Boffetta P" first="P." last="Boffetta">P. Boffetta</name>
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<country>France</country>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
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<affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Catalan Institute of Oncology (ICO-IDIBELL)</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Barcelone</settlement>
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<sZ>7 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Occupational Health, University of Milan</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="La Vecchia, C" sort="La Vecchia, C" uniqKey="La Vecchia C" first="C." last="La Vecchia">C. La Vecchia</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Epidemiology, Istituto di Ricerche Farmacologiche "Mario Negri</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Occupational Health, University of Milan</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Silverman, D" sort="Silverman, D" uniqKey="Silverman D" first="D." last="Silverman">D. Silverman</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Cancer Institute</s1>
<s2>Bethesda</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>National Cancer Institute</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Petersen, G M" sort="Petersen, G M" uniqKey="Petersen G" first="G. M." last="Petersen">G. M. Petersen</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Mayo Clinic</s1>
<s2>Rochester</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Mayo Clinic</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bracci, P M" sort="Bracci, P M" uniqKey="Bracci P" first="P. M." last="Bracci">P. M. Bracci</name>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>University of California - San Francisco</s1>
<s2>San Francisco</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">San Francisco</settlement>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ji, B T" sort="Ji, B T" uniqKey="Ji B" first="B. T." last="Ji">B. T. Ji</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Cancer Institute</s1>
<s2>Bethesda</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>National Cancer Institute</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bosetti, C" sort="Bosetti, C" uniqKey="Bosetti C" first="C." last="Bosetti">C. Bosetti</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Epidemiology, Istituto di Ricerche Farmacologiche "Mario Negri</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, D" sort="Li, D" uniqKey="Li D" first="D." last="Li">D. Li</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>MD Anderson Cancer Center</s1>
<s2>Houston</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Houston</settlement>
<region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gallinger, S" sort="Gallinger, S" uniqKey="Gallinger S" first="S." last="Gallinger">S. Gallinger</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Toronto General Hospital</s1>
<s3>USA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Toronto General Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Miller, A B" sort="Miller, A B" uniqKey="Miller A" first="A. B." last="Miller">A. B. Miller</name>
<affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Dalla Lana School of Public Health, University of Toronto</s1>
<s2>Toronto</s2>
<s3>CAN</s3>
<sZ>10 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
</author>
<author><name sortKey="Bueno De Mesquita, H B" sort="Bueno De Mesquita, H B" uniqKey="Bueno De Mesquita H" first="H. B." last="Bueno-De-Mesquita">H. B. Bueno-De-Mesquita</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>National Institute for Public Health and the Environment (RIVM)</s1>
<s2>Bilthoven</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<wicri:noRegion>National Institute for Public Health and the Environment (RIVM)</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Department of Gastroenterology and Hepatology, University Medical Center Utrecht (UMCU)</s1>
<s2>Utrecht</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Talamini, R" sort="Talamini, R" uniqKey="Talamini R" first="R." last="Talamini">R. Talamini</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Centro di Riferimento Oncologico (CRO) - National Cancer Institute</s1>
<s2>Aviano (PN)</s2>
<s3>ITA</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Centro di Riferimento Oncologico (CRO) - National Cancer Institute</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Polesel, J" sort="Polesel, J" uniqKey="Polesel J" first="J." last="Polesel">J. Polesel</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Centro di Riferimento Oncologico (CRO) - National Cancer Institute</s1>
<s2>Aviano (PN)</s2>
<s3>ITA</s3>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Centro di Riferimento Oncologico (CRO) - National Cancer Institute</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ghadirian, P" sort="Ghadirian, P" uniqKey="Ghadirian P" first="P." last="Ghadirian">P. Ghadirian</name>
<affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Epidemiology Research Unit, Research Center of the University of Montreal Hospital Centre (CRCHUM)</s1>
<s2>Montreal</s2>
<s3>CAN</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Baghurst, P A" sort="Baghurst, P A" uniqKey="Baghurst P" first="P. A." last="Baghurst">P. A. Baghurst</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Public Health, Women's and Children's Hospital</s1>
<s2>Adelaide</s2>
<s3>AUS</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Adelaide</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zatonski, W" sort="Zatonski, W" uniqKey="Zatonski W" first="W." last="Zatonski">W. Zatonski</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Cancer Center & Institute of Oncology</s1>
<s2>Warsaw</s2>
<s3>POL</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Pologne</country>
<wicri:noRegion>Cancer Center & Institute of Oncology</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Fontham, E" sort="Fontham, E" uniqKey="Fontham E" first="E." last="Fontham">E. Fontham</name>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Louisiana State University</s1>
<s2>New Orleans</s2>
<s3>USA</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Louisiana State University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bamlet, W R" sort="Bamlet, W R" uniqKey="Bamlet W" first="W. R." last="Bamlet">W. R. Bamlet</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Mayo Clinic</s1>
<s2>Rochester</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Mayo Clinic</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Holly, E A" sort="Holly, E A" uniqKey="Holly E" first="E. A." last="Holly">E. A. Holly</name>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>University of California - San Francisco</s1>
<s2>San Francisco</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">San Francisco</settlement>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gao, Y T" sort="Gao, Y T" uniqKey="Gao Y" first="Y. T." last="Gao">Y. T. Gao</name>
<affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Shanghai Cancer Institute</s1>
<s2>Shanghai</s2>
<s3>CHN</s3>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<wicri:noRegion>Shanghai Cancer Institute</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Negri, E" sort="Negri, E" uniqKey="Negri E" first="E." last="Negri">E. Negri</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Epidemiology, Istituto di Ricerche Farmacologiche "Mario Negri</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hassan, M" sort="Hassan, M" uniqKey="Hassan M" first="M." last="Hassan">M. Hassan</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>MD Anderson Cancer Center</s1>
<s2>Houston</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Houston</settlement>
<region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cotterchio, M" sort="Cotterchio, M" uniqKey="Cotterchio M" first="M." last="Cotterchio">M. Cotterchio</name>
<affiliation wicri:level="4"><inist:fA14 i1="08"><s1>Dalla Lana School of Public Health, University of Toronto</s1>
<s2>Toronto</s2>
<s3>CAN</s3>
<sZ>10 aut.</sZ>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
<orgName type="university">Université de Toronto</orgName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Population Studies and Surveillance, Cancer Care Ontario</s1>
<s2>Toronto</s2>
<s3>CAN</s3>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Toronto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Su, J" sort="Su, J" uniqKey="Su J" first="J." last="Su">J. Su</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Cancer Institute</s1>
<s2>Bethesda</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>National Cancer Institute</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Maisonneuve, P" sort="Maisonneuve, P" uniqKey="Maisonneuve P" first="P." last="Maisonneuve">P. Maisonneuve</name>
<affiliation wicri:level="3"><inist:fA14 i1="18"><s1>European Institute of Oncology</s1>
<s2>Milan</s2>
<s3>ITA</s3>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Boffetta, P" sort="Boffetta, P" uniqKey="Boffetta P" first="P." last="Boffetta">P. Boffetta</name>
<affiliation wicri:level="3"><inist:fA14 i1="19"><s1>International Prevention Research Institute</s1>
<s2>Lyon</s2>
<s3>FRA</s3>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="20"><s1>The Tisch Cancer Institute, Mount Sinai School of Medicine</s1>
<s2>New York</s2>
<s3>USA</s3>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Duell, E J" sort="Duell, E J" uniqKey="Duell E" first="E. J." last="Duell">E. J. Duell</name>
<affiliation wicri:level="3"><inist:fA14 i1="21"><s1>International Agency for Research on Cancer</s1>
<s2>Lyon</s2>
<s3>FRA</s3>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Catalan Institute of Oncology (ICO-IDIBELL)</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>Espagne</country>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Annals of oncology</title>
<title level="j" type="abbreviated">Ann. oncol.</title>
<idno type="ISSN">0923-7534</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Annals of oncology</title>
<title level="j" type="abbreviated">Ann. oncol.</title>
<idno type="ISSN">0923-7534</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alcoholic beverage</term>
<term>Analysis</term>
<term>Case control study</term>
<term>Consumption</term>
<term>Epidemiology</term>
<term>Ethanol</term>
<term>Human</term>
<term>International</term>
<term>Pancreas cancer</term>
<term>Risk factor</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Consommation</term>
<term>Boisson alcoolisée</term>
<term>Cancer du pancréas</term>
<term>Analyse</term>
<term>International</term>
<term>Homme</term>
<term>Etude cas témoin</term>
<term>Ethanol</term>
<term>Facteur risque</term>
<term>Epidémiologie</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Consommation</term>
<term>Boisson alcoolisée</term>
<term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background: Heavy alcohol drinking has been related to pancreatic cancer, but the issue is still unsolved. Methods: To evaluate the role of alcohol consumption in relation to pancreatic cancer, we conducted a pooled analysis of 10 case-control studies (5585 cases and 11 827 controls) participating in the International Pancreatic Cancer Case-Control Consortium. We computed pooled odds ratios (ORs) by estimating study-specific ORs adjusted for selected covariates and pooling them using random effects models. Results: Compared with abstainers and occasional drinkers (<1 drink per day), we observed no association for light-to-moderate alcohol consumption (<4 drinks per day) and pancreatic cancer risk; however, associations were above unity for higher consumption levels (OR = 1.6, 95% confidence interval 1.2-2.2 for subjects drinking ≥9 drinks per day). Results did not change substantially when we evaluated associations by tobacco smoking status, or when we excluded participants who reported a history of pancreatitis, or participants whose data were based upon proxy responses. Further, no notable differences in pooled risk estimates emerged across strata of sex, age, race, study type, and study area. Conclusion: This collaborative-pooled analysis provides additional evidence for a positive association between heavy alcohol consumption and the risk of pancreatic cancer.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Canada</li>
<li>Espagne</li>
<li>France</li>
<li>Italie</li>
<li>Pays-Bas</li>
<li>Pologne</li>
<li>République populaire de Chine</li>
<li>États-Unis</li>
</country>
<region><li>Auvergne-Rhône-Alpes</li>
<li>Californie</li>
<li>Catalogne</li>
<li>Lombardie</li>
<li>Ontario</li>
<li>Québec</li>
<li>Rhône-Alpes</li>
<li>Texas</li>
<li>Utrecht (province)</li>
<li>État de New York</li>
</region>
<settlement><li>Barcelone</li>
<li>Houston</li>
<li>Lyon</li>
<li>Milan</li>
<li>Montréal</li>
<li>San Francisco</li>
<li>Toronto</li>
<li>Utrecht</li>
</settlement>
<orgName><li>Université de Toronto</li>
</orgName>
</list>
<tree><country name="Italie"><region name="Lombardie"><name sortKey="Lucenteforte, E" sort="Lucenteforte, E" uniqKey="Lucenteforte E" first="E." last="Lucenteforte">E. Lucenteforte</name>
</region>
<name sortKey="Bosetti, C" sort="Bosetti, C" uniqKey="Bosetti C" first="C." last="Bosetti">C. Bosetti</name>
<name sortKey="La Vecchia, C" sort="La Vecchia, C" uniqKey="La Vecchia C" first="C." last="La Vecchia">C. La Vecchia</name>
<name sortKey="La Vecchia, C" sort="La Vecchia, C" uniqKey="La Vecchia C" first="C." last="La Vecchia">C. La Vecchia</name>
<name sortKey="Lucenteforte, E" sort="Lucenteforte, E" uniqKey="Lucenteforte E" first="E." last="Lucenteforte">E. Lucenteforte</name>
<name sortKey="Maisonneuve, P" sort="Maisonneuve, P" uniqKey="Maisonneuve P" first="P." last="Maisonneuve">P. Maisonneuve</name>
<name sortKey="Negri, E" sort="Negri, E" uniqKey="Negri E" first="E." last="Negri">E. Negri</name>
<name sortKey="Polesel, J" sort="Polesel, J" uniqKey="Polesel J" first="J." last="Polesel">J. Polesel</name>
<name sortKey="Talamini, R" sort="Talamini, R" uniqKey="Talamini R" first="R." last="Talamini">R. Talamini</name>
</country>
<country name="États-Unis"><noRegion><name sortKey="Silverman, D" sort="Silverman, D" uniqKey="Silverman D" first="D." last="Silverman">D. Silverman</name>
</noRegion>
<name sortKey="Bamlet, W R" sort="Bamlet, W R" uniqKey="Bamlet W" first="W. R." last="Bamlet">W. R. Bamlet</name>
<name sortKey="Boffetta, P" sort="Boffetta, P" uniqKey="Boffetta P" first="P." last="Boffetta">P. Boffetta</name>
<name sortKey="Bracci, P M" sort="Bracci, P M" uniqKey="Bracci P" first="P. M." last="Bracci">P. M. Bracci</name>
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   |texte=   Alcohol consumption and pancreatic cancer: a pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4)
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	Serveur d'exploration sur les relations entre la France et l'Australie
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Serveur d'exploration sur les relations entre la France et l'Australie

Alcohol consumption and pancreatic cancer: a pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4)

Alcohol consumption and pancreatic cancer: a pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4)

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